There's an irony at the heart of the treatment of high blood pressure. The malady itself often has no symptoms, yet the medicines to treat it — and to prevent a stroke or heart attack later — can make people feel crummy.
"It's not that you don't want to take it, because you know it's going to help you. But it's the getting used to it," says Sharon Fulson, a customer service representative from Nashville, Tenn., who is trying to monitor and control her hypertension.
The daily pills Fulson started taking last year make her feel groggy and nervous. Other people on the drugs report dizziness, nausea and diarrhea, and men, in particular, can have trouble with arousal.
"All of these side effects are worse than the high blood pressure," Fulson says.
Research shows roughly half of patients don't take their high blood pressure medicine as they should, even though heart disease is the leading cause of death in America. For many unfortunate people, their first symptom of high blood pressure is a catastrophic cardiac event. That's why hypertension is called the "silent killer."
A drug test is now available that can flag whether a patient is actually taking the prescribed medication. The screening, which requires a urine sample, is meant to spark a more truthful conversation between patient and doctor.
Fulson's blood pressure is a moving target, and when she shows me the way she usually checks it at home, it's a little high.
"Being on the radio might have an effect on me," she jokes. Even being in a doctor's office can add enough stress to elevate the results.
This is why taking patients' pressure — the familiar cuff test — doesn't confirm for cardiologists whether patients are consistently taking their hypertension meds. The new drug test, dubbed KardiAssure, uses computers to analyze urine to search for 80 kinds of blood pressure and cholesterol medication, reporting the results in just three minutes.
The test can determine only whether a patient has taken pills in the last day or two. But Aegis Sciences Corp.'s CEO Frank Basile says that's a starting point.
"What we give doctors is a tool that enables them to have a very focused conversation with their patients," he says. Only after the problem is out in the open, he says, can doctors get to the reasons behind it.
The conversation-starter has been effective for cardiologist Bryan Doherty in Dickson, Tenn., who has been working with Aegis to test the test. In one case, when the results showed a patient wasn't regularly taking his medicine, though he'd claimed he was, he quickly confessed.
"He immediately turned around and told me that the cost was an issue," Doherty says. "I think there was a degree of embarrassment there, potentially, or a feeling of letting me down in some way — something that had not come up in a 25-minute initial encounter when we had spoken before."
Of course, the test has a cost, too — about $100 — though Doherty notes that insurance, including Medicare, has been covering it.
The conversation is important, Doherty says, because he can try less expensive prescriptions if cost is the issue, or experiment with different kinds of drugs if side effects are the problem. It's worth the potentially uncomfortable encounter with the patient, he says, since the medication might make the difference between life and death.
The screening could also help a patient avoid other unnecessary tests or additional prescriptions, says Dr. Tom Johnston. He runs the hypertension clinic at Centennial Medical Center in Nashville and is board president of the local chapter of the American Heart Association.
Other than calling the pharmacy to make sure people are refilling their prescription, he says he generally takes their word for it.
"I think there are a lot of times where you're questioning in your mind whether someone has taken their medicine or not," he says. "I think it would be good for the patient, too, for the doctor to know that they're not taking their medicine so that we may not go down the wrong pathway."
Johnston, who is not affiliated with Aegis, says his only concern about using a drug test would be running the risk of setting up an adversarial relationship with a patient. But there's a way around that, too, he says, by making them understand how vital it is to take the drug properly.
Sarah Avery of Nashville says she's fully aware of the consequences.
"My daddy died because he didn't take his medicine," she says.
Hypertension runs in her family. Her mom and grandmother also battled high blood pressure. Still, the medication is such a drag, she's decided at times to stop without consulting her doctor.
"I lied. Really, I lied," she admits. "He said, 'Are you taking your medicine?' I said, 'Mmhmmm. Yeah, my momma makes sure that I do.' I was just lying," she says.
That is, until she, too, had a stroke. Now, she has three blood pressure medications and says she takes them without fail.
This story is part of NPR's reporting partnership with WPLN and Kaiser Health News.
NOEL KING, HOST:
There is an uncomfortable irony at the center of treatment for high blood pressure. High blood pressure itself often doesn't make people feel that bad, but the medicines used to treat it can make people feel lousy, so some people don't like taking their meds. Now a drug test is available to check if patients actually are taking them. Blake Farmer of member station WPLN in Nashville has the story.
SHARON FULSON: It's starting.
BLAKE FARMER, BYLINE: Sharon Fulson has her own blood pressure monitoring cuff at home because blood pressure is a moving target.
FULSON: Being on the radio might have an effect on me (laughter).
FARMER: Even being in a doctor's office can add enough stress to elevate their results. They call it white coat syndrome. And this is why testing a patient's blood pressure doesn't confirm for cardiologists whether a patient is taking the medication.
FULSON: It's not that you don't want to take it, because you know it's going to help you, but it's the getting used to it.
FARMER: The daily pills make Fulson feel groggy and nervous. Men can have trouble with arousal. Many report dizziness, nausea and diarrhea.
FULSON: All of these side effects is worse than the high blood pressure.
FARMER: Hypertension really doesn't have unpleasant symptoms until you have a stroke or a heart attack. That's why it's called the silent killer. Sarah Avery says hypertension runs in her family - her mother, grandmother and her late father.
SARAH AVERY: My daddy died because he didn't take his medicine.
FARMER: Still, the medication is such a drag, she's decided at times to stop without consulting her doctor.
AVERY: I lied. Really, I lied. He said, you taking your medicine? Mmm hmm. I said yeah, my momma made sure that I do. I was just lying.
FARMER: Research shows half of patients, maybe more, are like Avery and don't take their medicine like they should, even though heart disease is the leading killer in America. Avery had her own brush with death.
AVERY: I had a stroke, and that was because I wasn't taking my medicine.
FARMER: The medical community believes some of the complications could be avoided with better compliance. So this new drug test from Aegis Sciences may inject more honesty into the doctor-patient relationship.
(SOUNDBITE OF SCREENING MACHINE)
FARMER: Most of the time, this Nashville lab screens urine samples for drugs that shouldn't be there. This works the other way. Lab manager Jana Case says the machines search for all kinds of blood pressure and cholesterol medication.
JANA CASE: In that one injection, we can detect the 80-plus drugs. Results come out within about three minutes.
FARMER: The test only can tell whether a patient has taken pills in the last day or two, but CEO Frank Basile says it's at least a starting point.
FRANK BASILE: What we give doctors is a tool that enables them to have a very focused conversation with their patients, first of all, to bring the problem into the open and then to talk about, you know, exactly why.
FARMER: This has been effective for cardiologist Bryan Doherty, who works in a relatively rural Tennessee community. Tests he did on one man showed he hadn't been taking his medication.
BRYAN DOHERTY: He immediately turned around and told me that the cost was an issue. And I think there was a degree of, you know, embarrassment there, potentially, or feeling like he was letting me down in some way, something that had not come up in a 25-minute initial encounter when we'd spoken before.
FARMER: Of course, the test has a cost, too - about $100, though Doherty says insurance seems to cover it. And he says there are usually other drugs that are less expensive and other drug options that have fewer side effects. He says it's worth the potentially uncomfortable discussions between doctor and patient because the medication might make the difference between life and death. For NPR News, I'm Blake Farmer in Nashville.
KING: And that story was part of a reporting partnership with NPR, WPLN and Kaiser Health News. Transcript provided by NPR, Copyright NPR.