Nurith Aizenman

Across the United States the coronavirus is once again on the march. On Wednesday alone there were nearly 50,000 new cases — a record. The case counts for each state suggest the disease is mainly spreading in a band stretching from Florida across much of the southernmost states and westward to California, with Idaho and Iowa also in trouble.

But when you use tools to drill down to more local data, the picture gets more complicated — and even more concerning. Here are five takeaways:

It may be time for a statewide lockdown in Arizona and Florida

Just weeks after parts of the U.S. began reopening, coronavirus infections are on the upswing in several states, including Arizona, Utah, Texas and Florida. Dramatic increases in daily case counts have given rise to some unsettling questions: Is the U.S. at the start of a second wave? Have states reopened too soon? And have the recent widespread demonstrations against racial injustice inadvertently added fuel to the fire?

In an open letter to a top Trump Administration official, 77 Nobel prize-winning American scientists say they are "gravely concerned" about the recent abrupt cancellation of a federal grant to a U.S. non-profit that was researching coronaviruses in China.

More than 82,000 people in the United States have died of COVID-19 as of Tuesday. How many more lives will be lost? Scientists have built dozens of computational models to answer that question. But the profusion of forecasts poses a challenge: The models use such a wide range of methodologies, formats and time frames that it's hard to get even a ballpark sense of what the future has in store.

Updated on May 5 at 3:02 p.m. ET to include additional White House reactions.

On Monday the New York Times published what appeared to be an explosive finding: an internal document from the Trump Administration that forecast many more coming deaths from the coronavirus than the president has predicted publicly.

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Updated on May 1 at 10:50 a.m. ET

The U.S. government has suddenly terminated funding for a years-long research project in China that many experts say is vital to preventing the next major coronavirus outbreak.

Updated April 28, 5:00 p.m. ET

Across the U.S., state leaders are grappling with the challenging decision of when to relax the social distancing restrictions that have helped keep COVID-19 in check.

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President Trump and his top scientific advisers on the coronavirus task force gave a much-anticipated presentation Tuesday night, laying out the data behind the president's recent shift in tone regarding the outbreak, including his decision to extend national social distancing guidelines through April 30.

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Well, we better get used to social distancing.

(SOUNDBITE OF PRESS CONFERENCE)

As coronavirus infections rise across the United States, public health experts widely agree it's time for a drastic step: Every state in the nation should now issue the kind of stay-at-home orders first adopted by the hardest-hit places. And while most states will probably not need to keep the rules in place for months upon months, many health specialists say the lockdowns will need to be kept up for several weeks.

Yet among these same experts, there is debate when it comes to the natural next question: What strategy can be deployed after the lockdowns are lifted?

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Medstar Washington Hospital Center in Washington D.C. is in full-on preparation mode.

On a recent visit the staff had already marked out the parking lot — painting green rectangles to mark the places where tents are starting to be set up to screen arriving patients for COVID-19.

Even as the number of new coronavirus infections continues to spiral upward in countries around the world, a top global health expert says it's not too late to contain the virus.

"As long as you have these discrete outbreaks ... there is the opportunity to control them — to get on top of these and contain them and prevent a lot of disease and ultimately death," says Dr. Bruce Aylward, a senior adviser to the director-general of the World Health Organization. "That's the big message we saw in China — and one of the big surprises."

When it comes to the spiraling global coronavirus outbreak, scientists are still trying to pin down the answer to a basic question: How deadly is this virus?

Estimates have varied widely. For instance, at a Feb. 24 news conference in Beijing, a top Chinese health official, Liang Wannian, said the fatality rate for COVID-19 was quite high.

"Between 3 to 4% of patients have died," said Liang.

Three years ago, NPR accompanied disease ecologist Kevin Olival on a field trip to Malaysian Borneo.

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MARY LOUISE KELLY, HOST:

The number of people who are infected with the new coronavirus that is spreading from China is dwarfed by those affected by a far more common respiratory illness: seasonal flu.

Every year there are as many as 5 million severe flu cases worldwide and hundreds of thousands of deaths. By contrast, so far there have been about 20,000 (and rising) cases of coronavirus, most of them mild.

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